|
Carmen Dence, MS
Research Associate Professor of Radiology
|
Education
MS, Organic Chemistry, Florida State University, Tallahassee, FL 1972BS, Pharmaceutical Chemistry, Universidad del Atlantico, Columbia, SA 1967
Research Involvement
Among the different modalities to assess metabolism and to
diagnose pathological states in vivo is Positron Emission Tomography (PET). In our
laboratory, molecules labeled with short-lived isotopes are synthesized using fast
labeling techniques such as microwave irradiation and photolysis. The final products
are subjected to strict identification and quality control protocols with extensive
use of fast chromatographic techniques, before injection into animal or humans.
On-going research seeks probes for receptors-based systems, as well as for
metabolic studies of the brain and heart, using compounds labeled with carbon-11
(20.4 min half-life) and fluorine-18 (109.8 minutes half-life).
We are also interested in the development of target materials and techniques (including remote systems) to enhance the yields of nuclear reactions from cyclotrons.
We are also interested in the development of target materials and techniques (including remote systems) to enhance the yields of nuclear reactions from cyclotrons.
Selected Publications
1. Dence CS, Powers WJ, Welch MJ: Improved synthesis of 1-[11C]D-glucose. Appl Radiat Isot 1993; 44:971-980.
2. Dence CS, Welch MJ, Hughey BJ, Shefer RE, Klinkowstein RE: Production of [13N]ammonia applicable to low-energy accelerators. Nuc Med Biol 1994; 21:987-996.
3. Dence CS, Napolitano E, McCarthy TJ and Welch MJ: C-11 labeled estrogens as potential imaging agents for breast tumors. Nucl. Med Biol 1996; 23:491-496.
4. Mishani E, Dence CS, McCarthy TJ and Welch MJ: Formation of phenylpiperazines by a novel alumina supported bis-alkylation. Tetrahedron Letters 1996; 37:319-322.
5. Dence CS, John CS, Bowen WD and Welch MJ: Synthesis and evaluation of [F-18]labeled benzamides: High affinity sigma receptor ligands for PET imaging. Nucl. Med Biol 1997; 24:333-340.
6. Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Cryer PE and Powers WJ: Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in porly controlled type 1 diabetes. Diabetes 1998; 47:1444-1450.
2. Dence CS, Welch MJ, Hughey BJ, Shefer RE, Klinkowstein RE: Production of [13N]ammonia applicable to low-energy accelerators. Nuc Med Biol 1994; 21:987-996.
3. Dence CS, Napolitano E, McCarthy TJ and Welch MJ: C-11 labeled estrogens as potential imaging agents for breast tumors. Nucl. Med Biol 1996; 23:491-496.
4. Mishani E, Dence CS, McCarthy TJ and Welch MJ: Formation of phenylpiperazines by a novel alumina supported bis-alkylation. Tetrahedron Letters 1996; 37:319-322.
5. Dence CS, John CS, Bowen WD and Welch MJ: Synthesis and evaluation of [F-18]labeled benzamides: High affinity sigma receptor ligands for PET imaging. Nucl. Med Biol 1997; 24:333-340.
6. Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Cryer PE and Powers WJ: Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in porly controlled type 1 diabetes. Diabetes 1998; 47:1444-1450.
