Postdoctoral Fellow, University of California, San Francisco, CA 2008

PhD, Nuclear Chemistry, Simon Fraser University, Vancouver, Canada 2007

MSc, Nuclear Chemistry, Simon Fraser University, Vancouver, Canada 2003

BSc, Environmental Chemistry, Simon Fraser University, Vancouver, Canada 2001

My research interest is in the production and development of non-standard positron emitting radionuclides for Positron Emission Tomography (PET). These isotopes include ⁶⁴Cu, ⁸⁶Y, ⁸⁹Zr, and ⁹⁴mTc. These isotopes are produced with our small biomedical cyclotron by nuclear reactions on solid targets. One area of my research is to optimize production and separation of these isotopes in order to gain pure radionuclides which can be used to label molecules of interest for cancer applications.

Of particular interest is ⁸⁹Zr (t_1/2 = 3.27d). By conjugating this isotope to antibodies, biological information about tumors can be gained in a non-invasive manner.

1. Lapi, S.E., Wahhnishe, H., Pham, D., Wu., L.Y., Nedrow-Byers, J.R., Liu, T., VanBrocklin, H.F., Berkman, C.E. Jones, E.F., Assessment of a [18F]-labeled phosphoramidate peptidomimetic as a new PSMA targeted imaging agent for prostate cancer. Journal of Nuclear Medicine, in press
2. Lapi, S.E., Voller, T., Welch, M.J. (2009) Positron Emission Tomography Imaging of Hypoxia PET Clinics 4: 39-47
3. McGeer, P.M., Kornelson, R., McCormack, S., Ferreira, C., Lapi, S., Ruth, T.J. (2009) PET imaging in rats reveals that etanercept penetrates the CSF: implications for Alzheimer's disease. Journal of Alzheimer's Disease 18: 231-236
4. Kronenberg, A., Spejewski, E.H., Carter, H.K., Mervin, B., Jost. C., Stracener, D.W., Lapi, S., Bray, T. (2008) Molecular sidebands for refractory elements for ISOL. Nuclear Instruments and Methods B 266: 4252-4256
5. Annett, A. L., Lapi, S., Ruth, T.J., Maldonado, M.T. (2008) The effects of Cu and Fe availability on the growth and Cu:C ratios of marine diatoms. Journal of Limnology and Oceanography 53: 2451-2461
6. Ruprecht, G., Vockenhuber, C., Buchmann, L., Woods, R., Ruiz, C., Lapi, S., Bremmerer, D. (2008) Precise measurement of β-decay and EC modifications in low temperature metal hosts. Physics Review C 77: 065502
7. Ferreira, C.L., Lapi. S., Steele, J., Green, D.E., Ruth, T.J., Adam, M.J. (2007) ⁵⁵Cobalt Complexes with Pendant Carbohydrates as Potential PET Imaging Agents. Applied Radiation and Isotopes 65:1303-1308
8. Lapi, S.,Wilson, J., McQuarrie, S., Publicover, J., Schueller, M., Schyler, D., Ressler, J.J., Ruth, T.J. (2007) Measurement of production cross-sections of ^181-186Re isotopes from proton bombardment of natural tungsten. Applied Radiation and Isotopes 65: 345-349
9. Lapi, S., Ressler, J.J., Cox, M.E., Ruth, T.J., (2006) High-specific activity ¹⁸⁶Re-labeled antibodies for radioimmunotherapy. In Technetium, Rhenium and other metals in chemistry and nuclear medicine, U. Mazzi, ed, S.G. Editoriali, Padova, 2006. 593-596
10. Heath, S.J., Olson, J.A., Buckley, K. R., Lapi, S., Ruth, T.J., Martinez, D.M. (2007) Visualization of the flow of a fiber suspension through a sudden expansion using PET. American Institute of Chemical Engineering Journal 53: 327-334
11. Trinczek, M., Lapi, S, Guo, B., Ames, F., Buckley, K.R., D'Auria, J.M., Jayamanna, K., Liu, W.P., Ruiz, C., Ruth, T.J. (2006) Production of intense radioactive beams at ISAC using low energy protons. Canadian Journal of Physics 84: 323-333
12. Guo, B., Liu, W.P., Trinczek, M., Lapi, S., Ames, F., Buckley, K.R., D'Auria, J.M., Jayamanna, K., Ruiz, C., Ruth, T.J. (2006) Production of intense radioactive beams using low energy protons. High energy physics and nuclear physics (Chinese edition) 30: 675-679
13. Sossi, V., Buckley, K., Piccioni, P., Rahmin, A., Camborde, M., Lapi, S., Ruth, T.J. (2005) Printed Sources for Positron Emission Tomography. IEEE Nuclear Science 52: 114-118
14. Britto, D.T., Ruth, T.J., Lapi, S., Kronzucker. H.J. (2004) Cellular and whole-plant chloride dynamics in barley: Insights into chloride-nitrogen interactions and salinity responses Planta 218: 615-622
15. Lapi, S., Ruth, T.J., Zyuzin, A., D'Auria, J.M. (2003) Development of an intense ¹⁵O radioactive ion beam using low energy protons. Nuclear Instruments and Methods B 204: 444-446