BSc, Chemistry, Roanoke College, Salem, VA 1986

My research is focused on the development and utilization of molecular modeling techniques in order to understand the interactions of radiometal complexes with biological systems, and to design new ligands for the coordination of radiometals to be used for diagnostic imaging and therapy. This involves many areas of computational chemistry ranging from development of molecular mechanics forcefields to the utilization of density functional calculations, and QSAR studies of radiolabeled pharmaceuticals. Another area of research is in the design and development of novel MRI contrast agents. In conjunction with computational studies synthetic efforts are directed towards the development of new ligands with improved biological properties.