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Radiological Chemistry
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Dr Michael J Welch.
Michael J Welch, PhD
Professor of Radiology
Office: 4468B Clinical Sciences Research Building
Tel: 314.362.8436
Fax: 314.362.8399
welchm@wustl.edu
  
Washington University School of Medicine
Department of Radiological Sciences
Campus Box 8225
510 South Kingshighway
St. Louis, MO 63110-1016

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Education
PhD, Radiochemistry, University of London, England 1965
MA, Natural Sciences, Cambridge University, England 1964
BA, Natural Sciences, Cambridge University, England 1961

Professional History
Professor of Molecular Biology & Pharmacology 1993 - present
Department of Molecular Biology & Pharmacology,
Washington University School of Medicine, St. Louis, MO

Director 1990 - 2007
Division of Radiological Sciences,
Washington University, St. Louis, MO

Professor 1976 - present
Department of Chemistry,
Washington University, St. Louis, MO

Professor of Radiation Chemistry in Radiology 1974 - present
The Edward Mallinckrodt Institute of Radiology,
Washington University, St. Louis, MO

Associate Professor of Radiation Chemistry in Radiology 1970 - 1974
Washington University, St. Louis, MO

Assistant Professor of Radiation Chemistry in Radiology 1967 - 1970
Washington University, St. Louis, MO

Research Associate 1965 - 1967
Brookhaven National Laboratory, Upton, NY

Professional Activities
American Chemical Society
Member, Division of Nuclear Chemistry - Technology
The Royal Society of Chemistry(London)
The Radiation Research Society
Sigma Xi
International Symposia on Radiopharmaceutical Chemistry
Member, International Founding and Organizing Committee 1978 - present
The Society of Nuclear Medicine
Program Committee Member: 1969, 1972, 1975, 1982, 1983
President-Elect, Missouri Valley Chapter: 1975 - 1977
President, Missouri Valley Chapter: 1977 -1979
Program Committee Subchairman: 1978, 1979
Member, Board of Directors, Radiopharmaceutical Science Council: 1977 - 1979
Member, Board of Trustees, 1980 - 1990
President, Radiopharmaceutical Science Council: 1980 -1981
Program Committee Vice-Chairman: 1981, 1984
President Elect: 1983 - 1984
President: 1984 - 1985
Chairman, Awards Commitee: 1986 - 1988
General Program Chairman: 1988 - 1991
National Academy of Sciences
Member, Subcommittee on Nuclear and Radiochemistry: 1980 - 1982
Member, Committee on Nuclear and Radiochemistry: 1983 - 1986
Co-chairman, Workshop on Training Requirements for Chemists
in Nuclear Medicine, Nuclear Industry, and Related Areas, 1988
Diagnostic Radiology Study Section, NIH
Member: July 1986 - 1991
Chairman: 1989 - 1991
The Whitaker Foundation
Member, Scientific Advisory Committee: August 1995 - present
Institute of Medicine Clinical Research Roundtable
Member, Scientific Advisory Committee: June 2000 - present
Institute of Medicine
Member, Board on Health Science Policy: 2003 - present
Canada Research Chairs Program
Member, Review Committee: September 2000 - present

Research Involvement
My research involves the development of high resolution PET imaging techniques. The primary focus is on the developments of novel PET detectors and system suitable for imaging of small laboratory animals. To provide quantitative ../images, various data correction techniques are also investigated. The image reconstruction algorithm is another area of research that improve image resolution and quality with software. Multi-modality imaging that combines PET with CT or MRI to provide both functional and anatomical information has gain its popularity in clinical applications and is now ported into the small animal imaging research. The instruments and techniques developed have been applied to study new radiopharmaceuticals developed within the department, and to many collaborative projects that study human disease with transgenic mice and rats.

Selected Publications
  1. Welch, M.J. and Redvanly, C.S.: Handbook of Radiopharmaceuticals, Wiley, 2002.

  2. Sun, X., Wuest, M., Kovacs, Z., Sherry, A.D., Motekaitis, R., Wang, Z., Martell, A.E., Welch, M.J., Anderson, C.J.: In vivo behavior of copper-64-labeled methanephosphate tetraazamacrocyclic ligands. J Biol Inorg Chem 8: 217-225, 2003.

  3. Chapman, J.D., Bradley, J.D., Eary, J.F., Haubner, R., Larson, S.M., Michalski, J.M., Okunieff, P.G., Strauss, H.W., Ung, Y.C., Welch, M.J.: Molecular (functional) imaging for radiotherapy applications: an RTOG symposium. Int. J. Radiation Oncology Biol. Phys. 55(2):294-301, 2003.

  4. Oyama, N., Miller, T.R., Dehdashti, F., Siegel, B.A., Fischer, K.C., Michalski, J.M., Kibel, A.S., Andriole, G.L., Picus, J., Welch, M.J.: 11C-Acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse. J. Nucl. Med. 44(4):549-555, 2003.

  5. Rogers, B.E., Bigott, H.M., McCarthy, D.W., Manna, D.D., Kim, J., Sharp, T.L., Welch, M.J.: MicroPET imaging of a gastrin-releasing peptide receptor-positive tumor in a mouse model of human prostate cancer using a 64Cu-labeled bombesin analogue. Cancer Research. Submitted.

  6. Lewis, M.R., Wang, M., Axworthy, D.B., Theodore, L.J., Mallet, R.W., Fritzberg, A.R., Welch, M.J., Anderson, C.J.: In vivo evaluation of pretargeted copper-64 for tumor imaging and therapy. J. Nucl. Med., (in press).

  7. Dehdashti, F., Mintun, M.A., Lewis, J.S., Bradley, J., Govindan, R., Laforest, R., Welch, M.J., Siegel, B.A.: In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. Eur. J. Nucl. Med And Molecular Imaging., 30(6):844-850, 2003.

  8. Dehdashti, F., Grigsby, P.W., Mintun, M.A., Lewis, J.S., Siegel, B.A., Welch, M.J.: Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu- ATSM: relationship to therapeutic response - a preliminary report. Int. J. Radiation Oncology Biol. Phys. 55 (5):1233-1238, 2003.

  9. Vijaykumar, D., Al-Qahtani, M.H., Welch, M.J., Katzenellenbogen, J.A.: Synthesis and biological evaluation of a fluorine-18 labeled estrogen receptor-α selective ligand: [18F]propyl pyrazol triol. Nuclear Medicine Biology 30:397 - 404, 2003.

  10. Wang, Z.J., Bora, N.S., Sohn, J-H., Cruz, J.M., Nishihori, H., Nagengast, W.B., Welch, M.J., McCarthy, T.J., Kaplan, H.J. In vivo monitoring of T cell distribution using 64Cu-DOTA- CD4+ monoclonal antibody in rodents with a dedicated microPET scanner. J. Immunology Submitted.

  11. Mathias,C.J., Lewis,M.R., Reichert,D.E., Laforest,R., Sharp,T.L., Lewis,J.S., Yang, Z-F., Waters, D.J., Snyder,P.W., Low,P.S., Welch,M.J., Green,M.A. Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nuc Med and Bio 30:725-731, 2003.

  12. Aft, R.L., Lewis, J.S., Zhang, F., Kim, J-Y, Welch, M.J.: Enhancing targeted radiotherapy by 64Cu-ATSM using 2-Deoxy-D-Glucose. Cancer Research 63:5496-5504, 2003.

  13. Yoo, J., Reichert, D.E., Welch, M.J.: Regioselectiv N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers. Chem. Comm. 6:766-767, 2003.

  14. Oyama, N., Ponde, D.E., Dence, C., Kim, J., Tai, Y-C., Welch, M.J.: Monitoring of therapy in androgen dependent prostate tumor model by measuring tumor proliferation. J. Nucl. Med. (In press).

  15. Ponde, D.E., Dence, C.S., Schuster, D.P. Welch, M.J. Rapid and Reproducible Radiosynthesis of [18F] FHBG. Nucl Med and Biol. Submitted.

  16. Welch, M.J., Lewis, J.S. [Tc(CO)3]+ chemistry - A Promising New Concept for SPECT? Contra article. Eur J Nucl Med Molecular Imaging 30(9); 1302-1304, 2003.

  17. Welch, M.J., Halpern, H., Kurdziel, K.A. Example of Imaging Solutions to Multi-Disease Biological Challenge - Imaging of Hypoxia. Academic Radiology 10(8): 887-890, 2003.

  18. Obata, A., Kasamatsu,S., McCarthy,D.W., Welch,M.J., Saji,H., Yonekura,Y., Fujibayashi,Y. Production of therapeutic quantities of 64Cu using a 12 MeV cyclotron. Nuc Med and Bio 30:535-539, 2003.

  19. Obata, A., Yoshimoto,M., Kasamatsu,S., Naiki,H., Takamatsu,S., Kashikura,K., Furukawa,T., Lewis,J.S., Welch,M.J., Saji,H., Yonekura,Y., Fujibayashi,Y. Intra-tumoral distribution of 64Cu-ATSM: A comparison study with FDG. Nuc Med and Bio 30:529-534, 2003.

  20. Luyt, Leonard G., Bigott, Heather, M., Welch, Michael J., Katzenellenbogen, John A. 7α and 17α-Substituted Estrogens Containing Tridentate Tricarbonyl Rhenium/Technectium Complexes: Synthesis of Estrogen Receptor Imaging Agents and Evaluation Using MicroPET with Technetium-94m. Bioorganic & Medicinal Chemistry 11: 4977 - 4989, 2003.

  21. Zanzonico, P.B., Finn, R., Pentlow, K.S., Erdi, Y., Beattie, B., Humm, J. L., Akhurst, T., Squire, O., Morris, M., Scher, H., McCarthy, T., Welch, M., Larson, S.M. PET-based Radiation Dosimetry in Man of F18-Fluoro-dihydrotestosterone(FDHT), a New Radiotracer for Imaging Prostate Cancer. (in review).

  22. Lewis, J.S., Connett, J.M., Garbow, J.R., Buettner, T.L., Fujibayashi, Y., Fleshman, J.W., Welch, M.J.: Copper-64-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imaging. Cancer Research 62:445-449, 2002.

  23. Finck, B.N., Lehman, J.J., Leone, T.C., Welch, M.J., Bennett, M.J., Kovacs, A., Han, X., Gross, R.W., Kozak, R., Lopaschuk, G.D., Kelly, D.P.: The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus. J Clin Invest 109:121-130, 2002.

  24. McCarthy, T.J., Sheriff, A.U., Graneto, M.J., Talley, J.J., Welch, M.J.: Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors. J Nucl Med 43:117-124, 2002.

  25. Lewis, J.S. Achilefu, S., Garbow, J.R., Laforest, R., Welch, M.J.: Small animal imaging: current technology and perspectives for oncological imaging. Euro J Cancer 38:2173-2188, 2002.

  26. Jonson, S.D., Welch, M.J.: Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids. Nucl Med Biol 29:211-216, 2002.

  27. Sun, S., Wuest, M., Weisman, G.R., Wong, E.H., Reed, D.P., Boswell, C.A., Motekaitis, R., Martell, A.E., Welch, M.J., Anderson, C.J.: Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands. J Med Chem 45(2):469-477, 2002.

  28. Dearling, J.L.J., Lewis, J.S., Mullen, G.E.D., Welch, M.J., Blower, P.J.: Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships. J Biol Inorg Chem 7:249-259, 2002.

  29. McCarthy, T.J., Banks, W.A., Farrell C.L., Adamu, S., Derdeyn, C.P., Snyder, A.Z., Laforest, R., Litzinger, D.C., Martin, D., Lebel, C.P., Welch, M.J.: Positron emission tomography shows that intrathecal leptin reaches the hypothalamus in baboons. J Pharm and Exper Therap 301(3):878-883, 2002.

  30. Lewis, J.S., Herrero, P., Sharp, T.L., Engelbach, J.A., Fujibayashi, Y., Laforest, R., Kovacs, A., Gropler, R.J., Welch, M.J.: Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med 43:1557-1569, 2002.

  31. Lewis, M.R., Reichert, D.E., Laforest, R., Margenau, W.H., Shefer, R.E., Klinkowstein, R.E., Hughey, B.J., Welch, M.J.: Production and purification of gallium-66 for preparation of tumor-targeting radiopharmaceuticals. Nucl Med Biol 29:701-706, 2002.

  32. Chen, D., Sun, Y., Martell, A.E., Welch, M.J.: Two novel macrocyclic monooxo-tetraamines and the stabilities of their Cu(II) complexes. Inorg Chim Acta 335:119-124, 2002.

  33. Lewis, J.S., Welch, M.J.: Copper chemistry related to radiopharmaceutical production. Tc Chem Nucl Med 6:23-33, 2002.

  34. Vavere, A.L., Lewis, J.S., Welch, M.J.: Imaging of anti-angiogenic treatments: Ti-45- transferrin microPET as a surrogate marker for tumor response. Tc Chem Nucl Med 6:101- 105, 2002.

  35. Laforest, R., Rowland, D.J., Welch, M.J.: MicroPET imaging with non-conventional isotopes. IEEE Trans Nucl Sci 49(5):2119, 2002.

  36. Oyama, N., Kim, J., Jones, L.A., Mercer, N.M., Engelbach, J.A., Sharp, T.L., Welch, M.J.: MicroPET assessment of androgenic control of glucose and acetate uptake in the rate prostate and a prostate cancer tumor model. Nucl. Med. Biol. 29:783-790, 2002.

  37. Moerlein, S.M., Gaehle, G.G., Welch, M.J.: Robotic preparation of sodium acetate c-11 injection for use in clinical PET. Nucl. Med. Biol. 29:613-621, 2002.

  38. Rowland, D.J., Lewis, J.S., Welch, M.J.: Molecular imaging: the application of small animal positron emission tomography. J. Cell. Biochem. Suppl. 39:110-115, 2002.

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